Heart Regeneration with Embryonic Cardiac Progenitor Cells and Cardiac Tissue Engineering
نویسندگان
چکیده
منابع مشابه
Heart Regeneration with Embryonic Cardiac Progenitor Cells and Cardiac Tissue Engineering.
Myocardial infarction (MI) is the leading cause of death worldwide. Recent advances in stem cell research hold great potential for heart tissue regeneration through stem cell-based therapy. While multiple cell types have been transplanted into MI heart in preclinical studies or clinical trials, reduction of scar tissue and restoration of cardiac function have been modest. Several challenges ham...
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I n the Christian tradition, the doctrine of regeneration considers the " deceitful…and wicked " heart a vessel for accepting God and thereby being born again. Indeed, many cultures have invested the heart with powers well beyond its biological role in maintaining systemic perfusion. However, the capacity of the heart for renewal was limited to metaphor until relatively recently, when science r...
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New solutions are needed to regenerate hearts damaged by myocardial infarction, to overcome bad prognosis of patients with heart failure, and to address the shortage of heart donors. In the past few years, cardiac tissue engineering has emerged as a new and ambitious approach that combines knowledge from material chemistry with cell biology and medicine. In this short review, we present an over...
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Background: In spite of promising results of conventional treatments for myocardial infarction, including medications, stent implantation, and coronary artery bypass grafting, the disease and its complications, especially heart failure, are highly prevalent because these methods could not reverse the cell loss, which is the main problem. Currently, heart transplantation, as the last option f...
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Introduction: The direct approach of cardiac tissue engineering is to mimic the natural tissue of heart, considering the significant role of scaffolding and mechanical simulation. Methods: To achieve this purpose, a composite Polycaprolactone (PCL)/Gelatin electrospun scaffold with a ratio of 70:30 and with the most similarities to the cardiac extracellular matrix was fabricated with aligned ...
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ژورنال
عنوان ژورنال: Journal of Stem Cell and Transplantation Biology
سال: 2015
ISSN: 2469-5157
DOI: 10.19104/jstb.2015.104